Cytotec (ge. misoprostol, a.k.a. “miso”)

The obstetric community at large loves this drug. Some doctors refuse to use it at all, and some use it rarely. It’s a little white pill that as one person put it, “turns the cervix into absolute MUSHIE.” That’s the good side. But you know there has to be a bad side. First of all, notice the little picture of the pregnant woman with the big red slash over it. That obviously means it should not be given to pregnant women. The red rectangle on the side is a verbal description of why.

As a pharmacy tech for over 5 years, I’m well acquainted with drugs, their intended effects, and their side effects. All drugs have side effects. Sometimes this effect is so slight that people don’t even notice it; other times it’s overwhelming, or even deadly. Even something as innocuous as Tylenol (acetaminophen) can be deadly. Years ago, I read a story of a college student who accidentally overdosed on acetaminophen and required an emergency liver transplant, because she took several cold medicines and didn’t realize that all of them had acetaminophen in them.

Here is the package insert for Cytotec, taken from the FDA’s website. You should first know what this drug is–it’s to treat ulcers. They found out that it causes uterine contractions, which is why it’s contraindicated for pregnant women. I’ve heard of women inducing their own abortions by getting this medication and taking a few of them. The package insert says that after the 8th week of pregnancy, this drug can cause uterine rupture, but some abortion clinics’ websites I found said they use this drug in 2nd-trimester abortions.

But, after doctors found out that it can ripen an unfavorable cervix, it began to be used popularly in hospitals. I’ve heard more than one report that women are being given this without their knowledge, and/or without informed consent. One of my fellow childbirth educators was the first to tell an OB-resident of the potential dangers of this drug. He had never heard of the risks. Many women are just told that they’ll be given a pill (usually vaginally) to ripen their cervix. They are not told that this drug is contraindicated in pregnant women; nor are they told that it is an off-label use of the drug. What the doctors are doing is completely legal, but I consider it to be unethical not to give these women the full information.

Here is the information from the package insert about labor and delivery:

Cytotec can induce or augment uterine contractions. Vaginal administration of Cytotec, outside of its approved indication, has been used as a cervical ripening agent, for the induction of labor and for treatment of serious postpartum hemorrhage in the presence of uterine atony. A major adverse effect of the obstetrical use of Cytotec is hyperstimulation of the uterus which may progress to uterine tetany with marked impairment of uteroplacental blood flow, uterine rupture (requiring surgical repair, hysterectomy, and/or salpingo-oophorectomy), or amniotic fluid embolism. Pelvic pain, retained placenta, severe genital bleeding, shock, fetal bradycardia, and fetal and maternal death have been reported.

There may be an increased risk of uterine tachysystole, uterine rupture, meconium passage, meconium staining of amniotic fluid, and Cesarean delivery due to uterine hyperstimulation with the use of higher doses of Cytotec; including the manufactured 100 mcg tablet. The risk of uterine rupture increases with advancing gestational ages and with prior uterine surgery, including Cesarean delivery. Grand multiparity also appears to be a risk factor for uterine rupture.

In the year 2000, Searle (this drug’s manufacturer, since taken over by Pfizer) issued a letter of warning to health care providers who might consider using this drug to induce labor or cause an abortion. (My thanks to “americanmum” for reminding me of this!) It says in part:

“Serious adverse events reported following off-label use of Cytotec in pregnant women include maternal or fetal death; uterine hyperstimulation, rupture or perforation requiring uterine surgical repair, hysterectomy or salpingo-oophorectomy; amniotic fluid embolism; severe vaginal bleeding, retained placenta, shock, fetal bradycardia and pelvic pain.

Searle has not conducted research concerning the use of Cytotec for cervical ripening prior to termination of pregnancy or for induction of labor, nor does Searle intend to study or support these uses.”

You may be wondering why anybody uses it at all. This drug can ripen the cervix and/or induce labor. In the case of a medically indicated induction, many women have an unfavorable cervix, and the induction is likely to fail, thus necessitating a C-section. If Cytotec is used, and the cervix dilates and effaces, then the woman can have a vaginal birth and be spared a C-section. That’s a good thing. But at what cost?

Some doctors and even some midwives consider this benefit to be so good, and the risk of a ruptured uterus to be so slight, that they will use it. But isn’t that a choice for the patient to make? And shouldn’t the patient be given all of the information? That’s the simple idea behind “informed consent.” I will grant that most women do not have a problem with this drug. I will allow that most babies will survive with few negative sequelae after a Cytotec induction. But these are choices that the mother must make, weighing all the risks and benefits.

Here is a link to Ina May Gaskin’s website, where she has compiled a summary of articles about Cytotec’s use in labor. It has been quite some time since I’ve read it, but I remember that at least one trial was stopped because of the high rate of uterine ruptures in women who had had a C-section. I hope that if you’ve had a C-section, that your doctor will not use this drug on you, but he is legally allowed to use the drug any way he sees fit. The contraindication warning of this drug to pregnant women does not make it illegal to induce a woman with this drug.

In addition to the above article, here are some more true stories of women who have had negative outcomes from the use of this drug. No drug is 100% safe–not even Tylenol. When the benefit outweighs the risk, it makes sense to use it. But it is up to the person who takes the drug to decide the benefit-risk level.

This woman was induced for her 6th birth, and ended up nearly dying from a uterine rupture.

Here is a link to an investigative report that aired in Nashville, about the potential dangers of Cytotec.

Here is a link to a story that aired on CBS news a few years ago.

There are many other stories I could share, but I will let you conduct your own internet searches. The known disastrous side effects are rare but extremely serious. If you believe that Cytotec/misoprostol/miso should not be used on you, then you should discuss this with your doctor or midwife and have that in writing. Some of the doctors and nurses who have talked about this drug have such cavalier attitudes toward it that they may give it to you without even telling you what they’re doing, or giving you an option. But it’s your body, your baby, and should be your choice.

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30 Responses

  1. It is fascinating, that some OB’s will refuse moms the choice of having a VBAC for fear of uterine rupture, yet these same OB’s will use this drug all the time, even though it increases risk of uterine rupture. Great post, Thanks!

  2. Don’t forget too that Searle actually wrote a letter asking docs to please stop using cytotec for induction. Now was Searle’s motivation truly out of concern for pregnant women, or do they just not want to get sued? In any case, they are worried and that should be a clue to pregnant women and practitioners everywhere.

  3. [...] sure you are ok with the medications they are planning on using (if they say cytotec/misoprostol/miso do some research on [...]

  4. [...] to stop using it for their pregnant patients in 1971. [The FDA has also warned doctors not to use Cytotec for inducing labor, but they still do it [...]

  5. Wow, the more I read up about this drug, the more I am beginning to think it was the cause of my placental abruption and subsequent loss of my first baby in December 2007 at 34 weeks. Without having an autopsy performed on our baby, it’s likely we will never be able to pinpoint an exact cause, but I do know one thing: my baby was perfectly fine until the cytotec was administered. I can only hope more women read this, I had never even heard of this drug and I certainly signed a consent to have it used while in the hospital, but like your article mentioned, I was told that it was being used to riped my cervix for anticipated vaginal labor. However, none of the warnings or pertinent information was given to me at the time. Had I been sitting there with my laptop at the time, I would’ve researched it fully. I trusted the medical staff to keep me and my baby safe. Instead of bringing my healthy baby boy home, we had to plan his funeral at Christmas. Thank you for brining attention to this.

  6. [...] placenta, tatia oden french — Kathy @ 7:11 pm A while back I posted some information on Cytotec (an ulcer drug whose generic name is misoprostol, and is often called “miso” or just [...]

  7. [...] said she was “naive and unprepared,” she did know that she most certainly did not want Cytotec (a.k.a. “misoprostol”, “miso” or “the little white pill”) used [...]

  8. Drugs have to undergo rigorous safety trials to be approved of for use. They also have to carry information leaflets about side effects and potential risks. Surgery doesn’t have to do either of these and yet that doesn’t make it safer. It just makes patients more ignorant about the potential dangers of surgery. The surgical alternative to misoprostol is D&C (to treat retained products of conception following miscarriage or retained post partum placenta). D&C is INVASIVE and BLINDED surgery: the risks include a potential reaction to anesthesia including DEATH, and INFERTILITY from ASHERMAN’S SYNDROME due to injury to the basal endometrial layer (b/c the gyno can’t even see what he/she is scraping away at!). To treat Asherman’s syndrome (and hopefully regain some fertility) women must undergo further surgery, hormone therapy and often IVF. Pregnancies after treatment for Asherman’s syndrome are HIGH RISK FOR LIFE THREATENING COMPLICATIONS: PLACENTA ACCRETA, INCOMPETENT CERIX, INTRAUTERINE GROWTH RESTRICTION, PREMATURE RUPTURE OR MEMBRANES, UTERINE RUPTURE AND MATERNAL OR FETAL DEATH. IS IT WORTH IT? I say NO and I know because I got Asherman’s from ONE D&C. If I could do it again, I’d take misoprostol ie. miso the little white pill ANY DAY OVER A D&C!!

  9. In this post, I wasn’t comparing and contrasting Cytotec to D&C, but rather its use in women at or near term to induce labor with the intention of giving birth to a healthy, living baby. The alternatives to Cytotec in that instance are many (several different drugs or techniques, or simply watchful waiting and going into labor naturally), and most are less risky to mother and child than this drug.

    While much of this post was to highlight the risks of Cytotec to induce labor, the reason I even wrote the post is that many women are not told about the side effects and potential risks. Drugs given in hospitals don’t have patient information dispensed with them. Many times all the patient knows is what the drug is intended for (ripening the cervix, inducing labor), but not the name, side effects, or risks. These risks are many, but are primarily confined to use in women who are at or near term. The risks of Cytotec given after a miscarriage or after birth are bound to be less than that of a D&C. I’ve heard a doctor describe what a D&C is, and that would probably be my last option — I’d easily choose Cytotec over surgery, especially when the doctor really has no clue what he’s doing when he’s scraping away at a woman’s uterus. Most people probably assume the doctor can somehow “see” what he’s doing — it boggles my mind that most D&Cs are not performed with the benefit of ultrasound! I know (or strongly hope) that doctors develop a “feel” for how to do this, and how to tell when they need to stop scraping, but they can’t possibly be able to tell as well as they could with an ultrasound guiding their way. Many women have had a uterine puncture or perforation from a D&C (either after a miscarriage, or as part of an abortion); some have had to have hysterectomies, and others have even died from it, or a resulting infection.

    My problem with Cytotec is almost strictly its use to induce labor or ripen the cervix. It has killed mothers and babies — and these women are often never told of the known risks of the drug, and some aren’t even told that they’re going to be given the drug! While it can cause uterine rupture in a woman who is 8 weeks pregnant or more, the risk is nonexistent once the baby has been born (although it may possibly cause other problems), simply because the uterus is not swollen from pregnancy, or stretched around the baby at that point. At that point, the equation changes totally. Also, when used to evacuate the uterus after the fetus has died, the risk to the baby is nonexistent; and since the risk of uterine rupture goes up the further along in pregnancy the woman is, the woman just has to weigh the possible-but-unlikely risk of uterine rupture with Cytotec, and the risks of D&C that you wrote about (and very likely others).

    I’m going to assume that you were not told of those devastating risks of the D&C prior to your surgery. If that is the case, it makes me furious at your doctor. My main point about the use of Cytotec is that of informed consent. If you were unaware of the risks of your surgery, then what happened to you is the same thing that is happening every day in L&D units all over this country when this drug is given to uninformed women. And it makes me mad. And sad — very, very sad.

  10. Thanks for your reply Kathy. My gut feeling was that blind invasive surgery would be a big risk and sadly I turned out to be correct. However my Dr did NOT give me another choice and I asked about misoprostol, mifepristone as well as ultrasound guidance. I was told that at my stage of pregnancy drugs would not work (from what I’ve read though it can be used even in second trimester). The OR couldn’t accomodate an U/S. However I’ve since of heard of cases where Asherman’s STILL occurred after ultrasound guidance so the best thing is NO D&C. I waited to miscarry naturally but still couldn’t avoid a D&C due to RPOC. However to this day I don’t trust the Dr that claimed I had RPOC because he was VERY keen on doing a D&C. You say that the medical community loves prescribing misoprostol. Well,my impression is that they LOVE doing D&Cs. Surgery is not only more risky to women, it’s also much more costly. Surgery is 1000 US,miso 4 dollars. And we wonder why Drs prefer doing surgery.

    Misoprostol is on the WHO’s list of essential medicines for labour induction. It saves thousands of lives from post partum hemorrhage, especially in third world countries. It can prevent performing the dreaded D&C for retained placenta, preserving fertility. Reports about uterine rupture in women with past cesareans are controversial. I agree it needs further investigation in women with past c-sections. However D&Cs can lead to so much more damage. I agree that women should give consent for it’s use, but a lot of women also undergo ‘emergency’ D&Cs without consent.

    Your ‘evidence’ of misoprostol being ‘unsafe’ because the package says not to use it during pregnancy is very misleading. Please be honest and inform women that this is the case because originally misoprostol was created as a drug to treat ULCERS. They must have had unfortunately instances where women who were pregnant took the drug for ulcers and ended up miscarrying. It causes strong uterine contractions which is why it is used for many gynecological indications including treatment of miscarriage, postpartum hemorrhaging, to induce labour and cervical ripening. It is NOT harmful to the baby. It is only harmful if it is given to a woman who does not want to evacuate the uterus because it leads to miscarriage or preterm birth.

    Thank you.

  11. My personal opinion is that the medical community loves doing interventions, period. Whether we’re talking about C-sections, inductions of labor, D&Cs, or antibiotics for every presumed ear infection. I’m pretty “natural” minded in a lot of ways, and rarely take drugs (even aspirin or Tylenol) — I recognize that in that way, I am not “mainstream”. I believe you when you say your doctor was “very keen on doing a D&C” — from what I know of doctors from friends’ experiences and other people’s stories I’ve read, many doctors think every miscarriage requires a D&C, just like many doctors think every birth requires an induction, augmentation, episiotomy, or C-section. Sometimes they’re right; sometimes they’re wrong. It’s why I’m a strong advocate of informed consent, because it’s the woman who is going to end up paying the price if she ends up being on the “wrong side” of statistics. I also like second opinions when possible.

    Regarding the WHO, I found the application for misoprostol approval on that list and this, which says it’s the collective opinion of a group of experts, and not necessarily the stated decision of the WHO. The first document says, “WHO guidelines recommends using misoprostol for cervical (in labour induction) only in highly selected situations such as: (1) severe pre-eclampsia or eclampsia when the cervix is unfavourable and safe caesarean section is not immediately available or the baby is too premature to survive; (2) fetal death in-utero if the woman has not gone into spontaneous labour after 4 weeks and platelets are decreasing” (p. 2). Also, on p. 8 it lists the following adverse effects: “uterine hyperstimulation, is the most frequent adverse effect; it may be accompanied of fetal heart rate changes in about 5% to 10% of patients. Uterine rupture, particularly in women with scarred uterus. Fetal distress.” The 2nd document (p. 44-45) discusses miso’s use in abortions up until 9 weeks, and says that its effectiveness decreases further along in pregnancy (which is possibly why your doctor refused to use it; but as I stated in the original post, some abortion clinics advertise its use up through 24 weeks).

    Also, if you carefully reread the original post, you will see in the 3rd paragraph, that I said the drug is to treat ulcers; I’ve also got a link to the package insert, so anyone can go there and read all the information, which includes a section for patient information which thoroughly discusses its indicated use — for ulcers. We will have to disagree on whether or not Cytotec is harmful to the baby. With the potential for uterine rupture, amniotic fluid embolism, uterine hyperstimulation, and fetal distress (all of which carry the possibility of subsequent fetal demise; AFE also has a high mortality rate for women), I cannot say it is “NOT harmful to the baby.” As the WHO says, it should only be used in selected cases, and for medically indicated inductions. Many inductions in the US are done for non-medical or quasi-medical reasons, which means that women and babies are being put at a higher risk for many types of problems (since all inductions carry greater risk than natural labor) with no real benefit. The benefit of interfering or intervening is when the risk is greater to the mother and/or baby for continuing the pregnancy — such as with severe eclampsia. Women have been induced simply because the doctor was going on vacation, or the woman was tired of being pregnant — in other words, all the medical risks, with no medical benefit.

  12. Kathy, if you look at the scientific literature at PubMed you will see that miso can be used much later for miscarriage than 9 weeks. It may not be as effective, but it’s worth trying if it means possibly avoiding a D&C. I tried to get second opinions only to be told to wait 3 months!!! Can you believe how heartless some Dr receptionists are?

    I agree that drugs and interventions are overdone. But why focus on misoprostol? The risks you describe can occur from any drugs which induce labour, can’t they? One shouldn’t dismiss misoprostol simply because it can be used for abortion. So can D&C yet there is no one out there condemning D&Cs, just abortion- as if the same procedure is not used for miscarriage or retained placenta. Or as if it will only cause harm if done for abortion but is ‘safe’ for the other indications. So few people seem to be aware that D&Cs are routinely used in gynecology for all sorts of reasons, usually wrong reasons. Miso CAN save many lives if used properly and it won’t mutilate your reproductive organs like D&Cs can. See the study by Tam et al, 2002 which compares misprostol to D&C for miscarriages. Given the choice between D&C and misoprostol I know which I’d choose.

  13. Oh, I certainly agree with you about miso being used later than 9 weeks! If it didn’t work, abortion clinics wouldn’t have picked up on it for use in inducing abortions up through the 2nd trimester. I obviously don’t know the details of your case, nor am I a doctor, but it seems like you should have at least been given the option of *trying* Cytotec; and then if it failed, having a D&C (if it was necessary). While the WHO document I quoted said that miso becomes less effective after 9 weeks, somehow, I doubt that Cytotec would be “less effective” enough to render it not worth even attempting. It might not have worked (which might have been your doctor’s reasoning: “miso might not work, but D&C will, so we’ll just go with the sure thing”), but at least then you’d know. If I understand how Cytotec works to induce a miscarriage or abortion, it will work within a couple of days — was your situation so desperate that two days would have made a material difference? I’ve heard of women taking 6 weeks to fully miscarry. While the risk of infection increases the longer you wait, two days seems like a small time compared to several weeks. And it’s horrible that you were told you’d have to wait that long for a second opinion! It seems like there should have been a doctor somewhere willing to give you a few minutes to sit down with you and answer your concerns — which were certainly justified, considering the outcome. My opinion of your doctor grows worse and worse, the more I think about it.

    The main reason I’m focusing on misoprostol is that I’ve heard too many stories of women being given this drug to ripen the cervix or induce labor without any explanation of the potential side effects — and some not even told they were being given it at all. Its use in abortions was a non-issue when I began writing the post — it’s just not something I think too much about. Yes, I’m pro-life, but I don’t think about the different types of abortion and how they are accomplished. What made me include a side discussion about abortion is that it was mentioned in something I read when I wrote the original article (perhaps the package insert, perhaps an ad for an abortion clinic came up when I googled for stuff about misoprostol — I can’t remember right now). What I remember is not even wanting to include the info about abortion, lest someone read what I wrote and induce their own abortion. Not only is that immoral to me, but it could be quite dangerous to the woman, to have no medical supervision in the case of something going wrong (such as a hemorrhage).

    Let me restate that this post is about the use of Cytotec to induce labor or ripen the cervix in preparation for labor. Its other obstetric or gynecologic uses were not under consideration (except to discourage a self-induced abortion). I haven’t written at all about D&C. This is because I focus on childbirth, and D&Cs are typically used for miscarriages. I may in the future write about other things, including miscarriage, stillbirth, and infertility — I have posted a thing or two along those lines — mostly in passing, or links to other sites I found interesting. If I do write about D&Cs, you can be sure I’ll use the information you’ve given, including the study about D&Cs vs. miso. Unless I find something that would make me change my mind, if I ever had to choose between a D&C and Cytotec, I’d choose Cytotec too. We’re actually closer on this than you think.

  14. Yes, I guess we are.
    Here is some more info about the risks of developing Asherman’s syndrome after D&C (and this includes supposedly gentle suction D&C-the procedure used on me). It varies according to studies but according to one prospective study (Adoni et al, 1982), it occurred in 30.9% of women after missed miscarriage. The risks of getting Asherman’s from a postpartum D&C (for retained placenta or post partum hemorrhaging) is 25% (Parent et al,1979). In another study up to 40% of women with retained products of conception who underwent D&C developed the condition (Westendorp et al, 1998). These are statistics every woman should be told, rather than Asherman’s syndrome is ‘extremely rare’.

    I would advise any woman to opt for medical management of miscarriage or retained placenta. I hope that they are not put off Cytotech because of adverse publicity. It is also unfortunate that prolife groups are against drugs like misoprostol just because it could be used for abortion. It’s ironic that they are seemingly indifferent to exposing women that were actually trying to have a child to the dangers of D&C (which can also be used for abortion).

  15. We are agreed! And thanks for the info about Asherman’s syndrome — it’s just not something that I’ve encountered before, but I’m always ready to learn.

    My guess is that one reason pro-life groups may be against Cytotec but not against D&C is that Cytotec is new, while D&C has been around for ages. Because it was the only treatment that our mothers and grandmothers had, D&C is “accepted” for treatment of miscarriage without being linked so strongly (in our minds) with abortion. But Cytotec has probably been used more for abortions than for other reasons (including miscarriages, cervical ripening, etc.), or at least it has been more visible for abortions. Another factor may be possible confusion with RU-486 (the “abortion pill”) or the “morning-after pill.” It’s a knee-jerk reaction: Pills = bad. Just a guess.

  16. [...] Misoprostol can be a very dangerous drug to a pregnant woman and her baby. [...]

  17. I just wanted to say quick thank you for all of the great information. I have been induced 2 out of 2 pregnancies. Both over a week overdue and both over 9 lb healthy girls. With my first I was induced with Pitocin. The second with the cytotec pill. I believe that the staff at the hospital did not inform me about either of these procedures other than to say it was to induce labor, BUT I will say that I would choose the cytotec pill over pitocin ANY DAY OF THE WEEK. I know there are great risks with any unnatural induction like this, including the highly used pitocin. Those contractions were excruciatingly painful!! I think that the risks are definitely heightened in women with any sort of problems, and we should certainly get more info on these procedures BEFORE they are given so that we can make a well informed decision but this is true of any drug and just because the FDA says its ok or not does not mean we should completely take their word for it. They have been wrong before and I am convinced they are in cahoots with drug companies and disease control rather than prevention. So as a healthy woman with a healthy pregnancy that went very well, I was very pleased with the results of this pill compared to pitocin, which I will never do again. I would rather drink castor oil than be induced by pitocin again and that just sounds disgusting. :)

    You’re welcome! I’ve never had either, so have no personal base of comparison; however one of my friends called Pitocin “the drug from hell” which sure doesn’t make me want to use it! I’ve never had castor oil either, but agree that it sounds disgusting but would be my choice prior to either of these medications.
    – Kathy

  18. How Safe is cytotec in pregnancy induction?

  19. Mumba,

    It depends on who you ask. Many doctors and even midwives use it with little hesitation, while others absolutely will not use it. It is not something that I feel comfortable at all taking. There is a documented risk of uterine rupture even in an unscarred uterus, but definitely if the woman has had a previous C-section. Once given, it cannot be stopped but must “run its course”, even if the woman’s uterus goes into very intense contractions and causes fetal distress.

    The World Health Organization lists it as an approved medication for induction of labor when continuing the pregnancy is a risk to the mother or baby, and a safe C-section is not an option. In other words, if the mother is at risk for seizure and possibly death from eclampsia/ toxemia or some other big problem, then the benefits of Cytotec for induction outweigh the risks, if C-section cannot be safely performed.

  20. HI! I am 31 years old mother of two children. I find out i was 4 weeks pregnant in october 2011 its illegal to abort a child where i live so i secretly manage to get cytotec 200mg tablets from a source. It was my first time for its use i was told to swallow 4 tablets in early morning with empty stomach and 3 after 3 hours of first dose same way orally. I had diarrhoea symptoms along with slight uerine contractions but NO BLEEDING at all within a day cramps were over anmd i was fine again. had my ultrasound today and it shows a healthy fetus of 7 weeks with proper heart beat and my gynae when told abt my cytotec dose assured me that alone misoprostol is not dangerous for embryo unless its taken with mifepristone so i should continue the pregnancy. I am confused though whether should i go for medical abortion by travelling to another country or should i continue with this pregnancy. Please help me asap May God bless you always..”

    • Morally, you should continue with the pregnancy; the baby does not deserve to be killed just because you do not want to be pregnant. I cannot speak to the medical side of things, but would side with your doctor.

      • Thanks for your reply Kathy. Let me assure you i am also more than willing to continue with this pregnancy but just i am worried that my unborn is not harmed in any way..i am praying day and night please pray for my baby i am very ashamed on what i tried to did…May God forgive me…Amen

  21. I knew it was wrong as soon and the CNM talked me into using Cytotec but 12 years later websites like this confirm that it was probably what caused a life threatening Placenta accreta and had my son and myself transported to the ER.We suffered long term health issues from the early induction because he was big(but with immature lungs) and I had high blood pressure. Even if the cytotec didn’t cause the accreta it did cause the uneven cervical dilation that stalled delivery and made it more painful. I’m blessed that it didn’t cause a rupture given my age and the placental bleeding. Who knows if my son’s severe allergies and ADHD could have been prevented if I waited and had a C-section instead. He wouldn’t have been a 10 pound “premie” in the NICU needing oxygen and light therapy for jaundice if we wait til he was full term.

  22. I just wanted to share my recent experience, I too was given 2 “miso” pills to ripen my cervix at 41 weeks, then piton and I ended up nearly dying from a uterine rupture. I was rushed to the OR and had an emergency partial hysterectomy due to my bleeding. I lost half of my blood, luckily my son was delivered healthy. The day before going to the hospital I read online about this miso induction and read it could cause potential uterine rupture, when I told my doctor my concerns he told me they have been using it for years without any problems. I am lucky to be alive but would NEVER use this drug again.

  23. Hi, I have had cytotec twice. The first time was when I had a miscarriage at 10 weeks. The nurse came in,inserted the cytotec, and said I had to lay still for 30 minutes to ensure this medicine would help. They told me that having the cytotec was a safer option than going in for a surgical procedure at the hospital. An hour and a half later, I passed a fist-sized blood clot and they said that was normal. For days after that I had bad pain and contractions. The second time I was given cytotec was to help with the induction of my 5th baby,who was also a week overdue. They offered the every ‘6 hr drug’ or the every ’12 hr drug’. I chose the shorter timed one, in hoping my labor would progress nicely….6 hrs after having the first dose,came the second one. By the next day my pain was absolutely unbearable-it felt like my stomach was being ripped from the inside out-this coming from a mommy who has done this 4 other times and has a high pain tolerance for giving birth. I have never,ever felt pain like this. Then I thought-wow here comes my water…no, it was blood,I was bleeding and then suddenly came the blood clots. One after another, while we wondered what was happening-the doctors offered no answer-it was I don’t know why! My son was stunned while inside the womb and tried to push his head out sideways-not kidding…when he came out his head was swollen like a little cone head on the side and that was what they said. When he was born the cord was wrapped around his neck twice and he was not crying.They swooped in and got him to cry a very faint little cry. It was so sad and when they laid him on me he was completely lathargic.He didn’t move his arms around or cry and his eyes were glassy and gazed over. He looked completely out of it. They took him to the neonatal intensive care unit where he was placed on oxygen,iv, monitors for his heart and his pulse ox and he was in an incubator. His breathing was in destress because he had swallowed that blood that came out while I was in labor and it was in his lungs. I wasn’t allowed to hold him or stroke his little body. I was only allowed to put the tiniest bit of pressure to the bottom of his feet and the top of his little head. He started to do well, had a setback and then recovered amazingly! My son was in the nicu for 3 days and he got to come home with me. For the people who think of maybe taking a chance on the medicine- I hope this steers you away from it. Please remember that as scary and sad as this was for me, and for me to sit and retell this to you, there are people who lost their babies and some who lost their lives. You may be able to research it more and while looking, check out the cytotec petition that you will probably see. Maybe you will sign it…to make the fda put the warnings of this on the bottle and to stop the use of this for labor induction.

  24. Hi! just wanted to let all ladies know that even after cytotec high doses i decided to continue my pregnancy and God has blessed me with a beautifull and healthy baby girl. God is great :)

  25. Thanks a lot kathy :). I feared all the time and cursed myself for trying to abort her in the first place but God accept my plead for forgiveness and i am so happy now. My daughter is healthy and complete despite of my fears. Please dont abort your child ladies if abortion attempt doesnt work for you it simply means that you are the chosen one to bring that soul into this world. May God bless us all.

  26. I feel like I am in the never ending miscarriage. My body hates me I swear! And I am getting so frustrated.

    Well I took 2 misoclear Saturday night and another Sunday morning. I got some slight cramping and a backache. Slight bleeding only when I wiped. Not much. I took another one on Sunday night This time nothing. I feel so defeated. I just want this done and over with. I am trying to avoid a D&C at all costs.I want to move forward and put this behind me but my body is being stupid and not cooperating
    Anybody else have this happen to them? What did the Dr. do?

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